{"id":14339,"date":"2025-07-08T13:33:48","date_gmt":"2025-07-08T20:33:48","guid":{"rendered":"https:\/\/sparrowmd.ca\/?p=14339"},"modified":"2025-11-20T11:29:05","modified_gmt":"2025-11-20T19:29:05","slug":"pdrn-how-does-it-work","status":"publish","type":"post","link":"https:\/\/sparrowmd.ca\/cn\/pdrn\/pdrn-how-does-it-work\/","title":{"rendered":"The Science Behind PDRN | How Salmon DNA Works"},"content":{"rendered":"<h2>SALMON DNA FACIAL: HOW IT WORKS<\/h2>\n<p><a href=\"http:\/\/sparrowmd.ca\/cn\/salmon-dna-facial-vancouver\/\">PDRN treatments<\/a> are a cutting-edge innovation in skin regeneration.<\/p>\n\t<meta itemprop=\"name\" content=\"Salmon DNA Facial Vancouver: How does it work\" \/><meta itemprop=\"description\" content=\"Salmon DNA Facial Vancouver is a cutting edge innovation in skin regenerative treatment. What is the science behind salmon sperm facials or polynucleotide treatments?\" \/><meta itemprop=\"uploadDate\" content=\"2024-06-29T10:00-08:00\" \/><meta itemprop=\"thumbnailUrl\" content=\"https:\/\/sparrowmd.ca\/wp-content\/uploads\/2025\/03\/Website-Uploads2.png\" \/><meta itemprop=\"contentUrl\" content=\"https:\/\/youtu.be\/MmMGQqnjEAE?feature=shared\" \/><meta itemprop=\"embedUrl\" content=\"https:\/\/youtu.be\/MmMGQqnjEAE?feature=shared\" \/>\t\n\t<iframe allowfullscreen allow=\"autoplay\" data-src=\"https:\/\/www.youtube.com\/embed\/MmMGQqnjEAE?feature=oembed&amp;autoplay=1&amp;start&amp;end&amp;wmode=opaque&amp;loop=0&amp;controls=1&amp;mute=1&amp;rel=0&amp;modestbranding=0\"><\/iframe>\t\t\n\t\t\t\t\tPlay Video\n\t<p>They are DNA fragments purified and extracted from the sperm of salmon trout or chum salmon. As salmon DNA shares 95% similarity to human DNA, it is biocompatible with the human body. PDRN contains a mixture of double-stranded deoxyribonucleotides with a molecular weight ranging from 50 to 1,500 kDa. Furthermore, PDRN is scientifically proven to have multiple effects that can help improve skin health.<\/p>\n<h3>ANTI-INFLAMMATORY EFFECTS OF SALMON DNA<\/h3>\n<p>PDRN exerts its anti-inflammatory effects at the cellular level by activating adenosine A2A receptors and enhancing &#8220;salvage pathways.&#8221; These mechanisms target the oxidative stress that damages skin cells. By reducing the release of pro-inflammatory cytokines and stimulating anti-inflammatory cytokine production, PDRN regulates inflammation, which accelerates skin healing and promotes repair.<\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/sparrowmd.ca\/wp-content\/uploads\/2025\/03\/PDRN-salmon-DNA-Structure.png\" alt=\"PDRN salmon DNA structure at sparrow md\" itemprop=\"image\" height=\"867\" width=\"1442\" title=\"PDRN salmon DNA Structure\" onerror=\"this.style.display='none'\" loading=\"lazy\" \/>\n\t<h3>COLLAGEN SYNTHESIS PDRN<\/h3>\n<p>One of PDRN&#8217;s primary functions is to stimulate collagen production. By increasing fibroblast activity, PDRN helps to restore the skin&#8217;s natural collagen and elastin levels, counteracting the effects of intrinsic aging. This process supports the extracellular matrix (ECM) and helps maintain the skin&#8217;s structure, leading to firmer, more youthful-looking skin.<\/p>\n\t<a href=\"https:\/\/sparrowmd.ca\/cn\/book-now\/\" target=\"_self\" role=\"button\" aria-label=\"\u70b9\u51fb\u9884\u7ea6\">\n\t\t\t\t\t\t\u70b9\u51fb\u9884\u7ea6\n\t\t\t\t\t<\/a>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/sparrowmd.ca\/wp-content\/uploads\/2025\/03\/pdrn-helps-skin-aging-with-collagen-production.jpg\" alt=\"pdrn anti-aging vancouver salmon dna helps with collagen production\" itemprop=\"image\" height=\"522\" width=\"814\" title=\"pdrn helps with anti-aging vancouver sparrow md\" onerror=\"this.style.display='none'\" loading=\"lazy\" \/>\n\t<h3>ANGIOGENESIS AND TISSUE REPAIR BY PDRN<\/h3>\n<p>PDRN plays a critical role in tissue repair by enhancing the expression of vascular endothelial growth factor (VEGF), a protein that promotes the formation of new blood vessels. This process, known as <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2096691122000723\">angiogenesis<\/a>, improves blood flow to the skin, accelerating its natural healing and recovery.<\/p>\n\t<h3>SALMON DNA INHIBITION OF MELANIN SYNTHESIS<\/h3>\n<p>PDRN has been shown to inhibit tyrosinase, an enzyme responsible for melanin production. By reducing melanin synthesis, PDRN helps minimize the formation of dark spots and hyperpigmentation, which are common signs of skin aging. This makes PDRN an effective treatment for achieving a more even skin tone and reducing age-related discoloration.<\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/sparrowmd.ca\/wp-content\/uploads\/2025\/03\/PDRN-Salmon-DNA-Melanin-pigmentation.jpg\" alt=\"pdrn salmon sperm facial vancouver decrease melanin production\" itemprop=\"image\" height=\"524\" width=\"864\" title=\"pdrn facial vancouver decrease melanin production\" onerror=\"this.style.display='none'\" loading=\"lazy\" \/>\n\t<p>This microneedling process is an additional collagen stimulation aspect of our treatment. It further enhances the effect of PDRN to promote skin regeneration and repair. Upon completion of the procedure, our technician will implement a soothing post-care regimen to calm and hydrate the skin. This helps ensure a smooth recovery process. We will also provide you with a personalized post-care regimen, which typically includes our medical grade post care <a href=\"https:\/\/alastin.com\/products\/regenerating-skin-nectar\">nectar<\/a> to further support your skin healing.\u00a0<\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/sparrowmd.ca\/wp-content\/uploads\/2025\/03\/Website-Uploads2.png\" alt=\"salmon sperm facial vancouver with pdrn salmon dna\" itemprop=\"image\" height=\"720\" width=\"1280\" title=\"salmon dna facial vancouver\" onerror=\"this.style.display='none'\" loading=\"lazy\" \/>\n\t<h3><strong>IS IT RIGHT FOR YOU?<\/strong><\/h3>\nIn summary, PDRN therapy, derived from salmon DNA, offers advanced skin rejuvenation. This treatment enhances skin health by reducing inflammation, stimulating collagen production, promoting tissue repair, and reducing hyperpigmentation. PDRN helps regenerate skin, improve texture, and restore a more youthful appearance.\nNonetheless, it is important to remember that your skin care needs are unique. It is always best to book a consultation with a medical professional to see if it is the right treatment for you.\n<p>&nbsp;<\/p>\n\t<a href=\"https:\/\/sparrowmd.ca\/cn\/book-now\/\" target=\"_self\" role=\"button\" aria-label=\"BOOK CONSULTATION NOW\">\n\t\t\t\t\t\tBOOK CONSULTATION NOW\n\t\t\t\t\t<\/a>\n<h4>\n\t\t\tMedical Author\t<\/h4>\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/sparrowmd.ca\/wp-content\/uploads\/2024\/05\/58F77838-C439-45AE-83CF-E2BC5D089DC6-e1715943236453-150x150.jpeg\" alt=\"Dr. Zhai MD, CCFP\" \/>\n\t\t\t\t\t\t<h2>\n\t\t\t\t\t\t\t\t\t\t\t\tDr. Zhai MD, CCFP\n\t\t\t\t\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t<p>Dr. Jacqueline Zhai is a medical doctor with advanced training in aesthetic medicine. She is registered with the College of Physicians and Surgeons of BC (CPSBC). She is also a member of the American Society for Laser Medicine and Surgery (ASLMS) and the Canadian Association of Aesthetic Medicine (CAAM). Dr. Zhai focuses on delivering natural results that are tailored to each and every one of her patients. She is passionate about providing her clients with the most advanced and up-to-date treatment options. Dr. Zhai and her team are constantly updating their knowledge and translating this into patient care. Dr. Zhai loves both the artistic and personal nature of her work. She dedicates her work to helping her clients look and feel confident at any age.<\/p>\n\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/author\/jzhai\/\" target=\"_self\">\n\t\t\t\t\t\t\tView Articles\n\t\t\t\t\t\t<\/a>\n\t\t<h3>\n\t\t\tLEARN ABOUT OUR TREATMENTS\n\t\t<\/h3>\n\t\t<ul>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>Neuromodulator\/Botox\u00ae<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e6%b8%a9%e5%93%a5%e5%8d%8e-%e8%82%89%e6%af%92%e6%9d%86%e8%8f%8c-%e7%a5%9e%e7%bb%8f%e8%b0%83%e8%b4%a8-2\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u73bb\u5c3f\u9178<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e7%8e%bb%e5%b0%bf%e9%85%b8-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u5fae\u9488\u6cbb\u7597<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e5%be%ae%e9%92%88-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u8d85\u58f0\u5200Ultherapy\u00ae<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e8%b6%85%e5%a3%b0%e5%88%80-%e7%b4%a7%e8%87%b4%e7%9a%ae%e8%82%a4-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u5916\u6ccc\u4f53<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e5%a4%96%e6%b3%8c%e4%bd%93\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u4e86\u89e3\u9762\u90e8\u6297\u8870<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e6%8a%97%e8%a1%b0\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>360 Wellness<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/ozempic-vancouver-clinic\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u75e4\u75ae\u75a4\u75d5\u5265\u79bb\u672f <\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e7%9a%ae%e4%b8%8b%e5%88%86%e7%a6%bb%e6%9c%af-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>Trapezius Botox<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e8%82%a9%e9%83%a8-botox%e6%b2%bb%e7%96%97-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u7626\u8138\u9488<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e7%98%a6%e8%84%b8%e9%92%88\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>Hair Loss <\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e8%84%b1%e5%8f%91-%e6%b2%bb%e7%96%97-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\uff08\u6cd5\u56fd\u7ae5\u989c\u9488Sculptra\u00ae\u5851\u7136\u96c5\uff09<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e7%ab%a5%e9%a2%9c%e9%92%88-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li>\n\t\t\t\t<h4>\u5fb7\u56fd\u5fae\u6676\u74f7Radiesse\u00ae\u745e\u5f97\u559c<\/h4>\n\t\t\t\t\t\t\t<a href=\"https:\/\/sparrowmd.ca\/cn\/%e7%91%9e%e5%be%b7%e5%96%9c%e5%be%ae%e6%99%b6%e7%93%b7-%e6%b8%a9%e5%93%a5%e5%8d%8e\/\" target=\"_self\">\u4e86\u89e3\u66f4\u591a<\/a>\n\t\t\t<\/li>\n\t\t\t\t<\/ul>","protected":false},"excerpt":{"rendered":"<p>SALMON DNA FACIAL: HOW IT WORKS PDRN treatments are a cutting-edge innovation in skin regeneration. Play Video They are DNA fragments purified and extracted from the sperm of salmon trout or chum salmon. As salmon DNA shares 95% similarity to human DNA, it is biocompatible with the human body. PDRN [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":14318,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[92,95,101,117,118,137,138],"tags":[127,132,139,141,142],"class_list":["post-14339","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-collagen","category-microneedling","category-skin-rejuvenation","category-beauty","category-skincare","category-pdrn","category-anti-aging","tag-microneedling","tag-skincare","tag-pdrn","tag-salmon-sperm-facial","tag-salmon-dna-facial"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.1 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>The Science Behind PDRN | How Salmon DNA Works<\/title>\n<meta name=\"description\" content=\"The Salmon DNA PDRN facial at our clinic in Vancouver is an advanced anti-aging treatment. How does it work to improve skin health?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sparrowmd.ca\/cn\/pdrn\/pdrn-how-does-it-work\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Science Behind PDRN | How Salmon DNA Works | Self Care Starts Here\" \/>\n<meta property=\"og:description\" content=\"Sparrow MD&#039;s doctors specialize in customized non-surgical medical aesthetic treatments and skincare strategies for all ages and genders.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sparrowmd.ca\/cn\/pdrn\/pdrn-how-does-it-work\/\" \/>\n<meta property=\"og:site_name\" content=\"Sparrow MD\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sparrowmd.inc\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-08T20:33:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-20T19:29:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sparrowmd.ca\/wp-content\/uploads\/2025\/03\/salmon-sperm-DNA-vancouver-PDRN-2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1035\" \/>\n\t<meta property=\"og:image:height\" content=\"1071\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Dr. Zhai MD, CCFP\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@sparrowmd1\" \/>\n<meta name=\"twitter:site\" content=\"@sparrowmd1\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dr. Zhai MD, CCFP\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 \u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/\"},\"author\":{\"name\":\"Dr. Zhai MD, CCFP\",\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/#\\\/schema\\\/person\\\/47a5ea140ad19c3c2f811a1b8c989931\"},\"headline\":\"The Science Behind PDRN | How Salmon DNA Works\",\"datePublished\":\"2025-07-08T20:33:48+00:00\",\"dateModified\":\"2025-11-20T19:29:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/\"},\"wordCount\":654,\"publisher\":{\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sparrowmd.ca\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Salmon_DNA_skincare_technolocy_480x480.webp\",\"keywords\":[\"microneedling\",\"skincare\",\"pdrn\",\"salmon sperm facial\",\"salmon dna facial\"],\"articleSection\":[\"Collagen\",\"Microneedling\",\"Skin Rejuvenation\",\"Beauty\",\"skincare\",\"PDRN\",\"Anti-aging\"],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/\",\"url\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/\",\"name\":\"The Science Behind PDRN | How Salmon DNA Works\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sparrowmd.ca\\\/pdrn\\\/pdrn-how-does-it-work\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sparrowmd.ca\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Salmon_DNA_skincare_technolocy_480x480.webp\",\"datePublished\":\"2025-07-08T20:33:48+00:00\",\"dateModified\":\"2025-11-20T19:29:05+00:00\",\"description\":\"The Salmon DNA PDRN facial at our clinic in Vancouver is an advanced anti-aging treatment. 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